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Multi-omics analysis of primary glioblastoma cell-lines shows recapitulation of pivotal molecular features of parental tumors

ABSTRACT: The goal of the study was to describe and compare the genomic landscape of Glioblastoma parental tumors and PAIRED patient derived cell lines(PDCLs). This approach enables to examine and estimate the extent to which PDCLs recapitulates the genome landscape of parental tumors - which is important for experimental model validation. In addition the consistent differences between tumors and PDCL can be evaluated in order to identify the model's weak points. In the enclosed data set, copy number variation analysis for 10 pairs of Glioblastoma tumors and their paired PDCLs are given(20 samples). Complementary data on transcriptome have been deposited at ArrayExpress under accession number E-MTAB-4803 (http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-4803).

ORGANISM(S): Homo sapiens

SUBMITTER: Shai Rosenberg

PROVIDER: E-MTAB-4804 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Multi-omics analysis of primary glioblastoma cell-lines shows recapitulation of pivotal molecular features of parental tumors

Project description:The goal of the study was to describe and compare the genomic landscape of Glioblastoma parental tumors and PAIRED patient derived cell lines(PDCLs). This approach enables to examine and estimate the extent to which PDCLs recapitulates the genome landscape of parental tumors - which is important for experimental model validation. In addition the consistent differences between tumors and PDCL can be evaluated in order to identify the model's weak points. In the enclosed experiment, nine pairs of Glioblastoma tumors and paired PDCL (18 samples) were analyzed for transcriptome. Complementary data on copy-number variation have been deposited at ArrayExpress under accession number E-MTAB-4804 (http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-4804).

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