Transcriptome profiling of dedifferentiating smooth muscle cells from mouse aorta and bladder

ABSTRACT: Smooth muscle cells (SMCs) are important in a number of physiological systems and organs, including the cardiovascular system. The hallmark property of differentiated SMCs is the ability to contract, but contractile SMCs themselves show a range of phenotypes allowing prolonged tonic contraction in vascular smooth muscle or rapid phasic contraction in tissues such as bladder. Another distinctive characteristic, in contrast with terminally differentiated striated muscle cells, is that SMCs exhibit phenotypic plasticity. Vascular SMCs are able to modulate their phenotype along a continuum between a contractile phenotype, characteristic of healthy blood vessels, and a more proliferative “synthetic” phenotype, so-named for the enhanced synthesis and secretion of extracellular matrix compone

ORGANISM(S): Mus musculus

SUBMITTER: Chris Smith 

PROVIDER: E-MTAB-4841 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress