Dataset Information

Novel role of LRP1 in the regulation of smooth muscle contractile function by regulating cytoskeletal dynamics and Ca2+ signaling.

ABSTRACT: This project contains the proteomics data for the manuscript "Novel role of LRP1 in the regulation of smooth muscle contractile function by regulating cytoskeletal dynamics and Ca2+ signaling." by Au et al.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Aorta Thoracica

DISEASE(S): Cardiovascular System Disease

SUBMITTER: William Fondrie

LAB HEAD: Dudley K Strickland

PROVIDER: PXD007544 | Pride | 2018-10-22

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	150716-s2196_1-s2196_3-erlic-01.RAW	Raw
	150720-s2196_1-s2196_3-erlic-02.RAW	Raw
	150720-s2196_1-s2196_3-erlic-03.RAW	Raw
	150720-s2196_1-s2196_3-erlic-04.RAW	Raw
	150720-s2196_1-s2196_3-erlic-05.RAW	Raw

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Publications

LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca<sup>2+</sup> Signaling and Expression of Cytoskeleton-Related Proteins.

Au Dianaly T DT Ying Zhekang Z Hernández-Ochoa Erick O EO Fondrie William E WE Hampton Brian B Migliorini Mary M Galisteo Rebeca R Schneider Martin F MF Daugherty Alan A Rateri Debra L DL Strickland Dudley K DK Muratoglu Selen C SC

Arteriosclerosis, thrombosis, and vascular biology 20181101 11

Objective- Mutations affecting contractile-related proteins in the ECM (extracellular matrix), microfibrils, or vascular smooth muscle cells can predispose the aorta to aneurysms. We reported previously that the LRP1 (low-density lipoprotein receptor-related protein 1) maintains vessel wall integrity, and smLRP1<sup>-/-</sup> mice exhibited aortic dilatation. The current study focused on defining the mechanisms by which LRP1 regulates vessel wall function and integrity. Approach and Results- Iso ...[more]

PMID: 30354243

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