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WTCHG - Mouse - Liver transcriptome adaptations to high fat diet

ABSTRACT: The effect of high fat diet feeding on liver gene transcription regulation was investigated in BALB/c mice using Affymetrix gene expression arrays. Expression data was determined in 5 months old male mice fed a high fat diet (40% fat) for 15 weeks. Control mice were fed a standard carbohydrate chow. Six animals per group were used.

ORGANISM(S): Mus musculus

SUBMITTER: Georg Otto 

PROVIDER: E-MTAB-488 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Nutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome.

Waller-Evans Helen H   Hue Christophe C   Fearnside Jane J   Rothwell Alice R AR   Lockstone Helen E HE   Caldérari Sophie S   Wilder Steven P SP   Cazier Jean-Baptiste JB   Scott James J   Gauguier Dominique D  

PloS one 20131206 12

Nutritional factors play important roles in the etiology of obesity, type 2 diabetes mellitus and their complications through genotype x environment interactions. We have characterised molecular adaptation to high fat diet (HFD) feeding in inbred mouse strains widely used in genetic and physiological studies. We carried out physiological tests, plasma lipid assays, obesity measures, liver histology, hepatic lipid measurements and liver genome-wide gene transcription profiling in C57BL/6J and BAL  ...[more]

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