Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of Staphylococcus aureus treated with tigecycline to determine the effect of the expression of virulence factors in biofilm-associated cells

ABSTRACT: Data is also available from BuG@Sbase

ORGANISM(S): Staphylococcus aureus

SUBMITTER:

PROVIDER: E-BUGS-81 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Influence of tigecycline on expression of virulence factors in biofilm-associated cells of methicillin-resistant Staphylococcus aureus.

Smith Karen K Gould Katherine A KA Ramage Gordon G Gemmell Curtis G CG Hinds Jason J Lang Sue S

Antimicrobial agents and chemotherapy 20091026 1

Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells within the biofilm may be exposed to a sublethal concentration of the antimicrobial due to the metabolic and phenotypic diversity of the biofilm-associated cells or the protection offered by the biof ...[more]

PMID: 19858261

Similar Datasets

Comparative genomic hybridization by array of Streptococcus pneumoniae isolates from the Mitis group to identify pneumococcal virulance genes

Project description:Data is also available from <ahref=http://bugs.sgul.ac.uk/E-BUGS-82 target=_blank>BuG@Sbase</a>

2010-07-22 | E-BUGS-82 | biostudies-arrayexpress

Transcription profiling of Mycobacterium tuberculosis after treatment with ciprofloxacin to investigate the SOS DNA repair response

Project description:Data is also available from http://bugs.sgul.ac.uk/E-BUGS-63

2008-09-26 | E-BUGS-63 | biostudies-arrayexpress

Transcription profiling of Mycobacterium tuberculosis infected human dendritic cells and macrophages and M. tuberculosis grown aerobically to investigate host-pathogen cross-talk

Project description:Data is also available from http://bugs.sgul.ac.uk/E-BUGS-58

2008-01-04 | E-BUGS-58 | biostudies-arrayexpress

Responses of Staphylococcus aureus exposed to HCl and organic acid stress.

Project description:Staphylococcus aureus is an important food poisoning bacterium. In food preservation, acidification is a well-known method. Permeant weak organic acids, like lactic and acetic acids, are known to be more effective against bacteria than inorganic strong acids (e.g., HCl). Growth experiments and metabolic and transcriptional analyses were used to determine the responses of a food pathogenic S. aureus strain exposed to lactic acid, acetic acid, and HCl at pH 4.5. Lactic and acetic acid stress induced a slower transcriptional response and large variations in growth patterns compared with the responses induced by HCl. In cultures acidified with lactic acid, the pH of the medium gradually increased to 7.5 during growth, while no such increase was observed for bacteria exposed to acetic acid or HCl. Staphylococcus aureus increased the pH in the medium mainly through accumulation of ammonium and the removal of acid groups, resulting in increased production of diacetyl (2,3-butanedione) and pyrazines. The results showed flexible and versatile responses of S. aureus to different types of acid stress. As measured by growth inhibition, permeant organic acid stress introduced severe stress compared with the stress caused by HCl. Cells exposed to lactic acid showed specific mechanisms of action in addition to sharing many of the mechanisms induced by HCl stress. Data is also available from http://bugs.sgul.ac.uk/E-BUGS-87

2011-04-15 | E-BUGS-87 | biostudies-arrayexpress

Transcription profiling of Campylobacter jejuni flagellar mutants to investigate the RpoN and FliA regulons, and the flagellar hook length control gene fliK

Project description:Data is also available from http://bugs.sgul.ac.uk/E-BUGS-50

2007-09-06 | E-BUGS-50 | biostudies-arrayexpress

Transcription profiling of Mycobacterium tuberculosis using a transposon mutagenesis approach to elucidate pe/ppe regulation

Project description:Data is also available from <ahref=http://bugs.sgul.ac.uk/E-BUGS-91 target=_blank>BuG@Sbase</a>

2009-08-18 | E-BUGS-91 | biostudies-arrayexpress

Methionine Sulfoximine Resistance in Mycobacterium tuberculosis Is Due to a Single Nucleotide Deletion Resulting in Increased Expression of the Major Glutamine Synthetase, GlnA1.

Project description:We investigated the effect of methionine sulfoximine (MetSox), a potent inhibitor of glutamine synthetase, on Mycobacterium tuberculosis. M. tuberculosis encodes four glutamine synthetases, of which MetSox targets the type I enzyme encoded by glnA1. Trancriptional profiling revealed that glutamate synthetase (gltB) and a type II glutamine synthetase (glnA3) were induced after exposure to MetSox. In addition, we observed a high rate (10(-5)) of spontaneous resistance to MetSox. All resistant strains had a single-nucleotide deletion in the 5' region of glnA1, and Western analysis revealed that GlnA1 expression was increased in resistant as compared with sensitive strains. These data show that M. tuberculosis can respond to the effect of MetSox inhibition either by up-regulation of GlnA3 or by GlnA1. The high frequency of resistance suggests that MetSox and other compounds specifically targeting GlnA1 are not likely to become successful anti-mycobacterial agents. Data is also available from http://bugs.sgul.ac.uk/E-BUGS-112

2011-09-06 | E-BUGS-112 | biostudies-arrayexpress

Transcription profiling of Mycobacterium tuberculosis treated with benzothiazinones which kill M. tuberculosis by blocking arabinan synthesis

Project description:Data is also available from <ahref=http://bugs.sgul.ac.uk/E-BUGS-80 target=_blank>BuG@Sbase</a>

2009-03-19 | E-BUGS-80 | biostudies-arrayexpress

Transcription profiling of mouse fetal liver cells obtained from MBT-1+/+ or MBT-1-/- embryos at E14.5

Project description:Gene expression in the fetal liver cells obtained from MBT-1+/+ or MBT-1-/- embryos at E14.5 were analyzed using Affymetrix Genechip to assess the effect of the gene knock-out on hematopoietic cells.

2004-11-30 | E-MEXP-219 | biostudies-arrayexpress

Transcription profiling of Haemophilus influenzae cells to characterize dependence of competence-induced transcription on known regulatory factors

Project description:Data is also available from http://bugs.sgul.ac.uk/E-BUGS-20

2007-01-30 | E-BUGS-20 | biostudies-arrayexpress