Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of Staphylococcus aureus treated with tigecycline to determine the effect of the expression of virulence factors in biofilm-associated cells


ABSTRACT: Data is also available from BuG@Sbase

ORGANISM(S): Staphylococcus aureus

SUBMITTER:  

PROVIDER: E-BUGS-81 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Influence of tigecycline on expression of virulence factors in biofilm-associated cells of methicillin-resistant Staphylococcus aureus.

Smith Karen K   Gould Katherine A KA   Ramage Gordon G   Gemmell Curtis G CG   Hinds Jason J   Lang Sue S  

Antimicrobial agents and chemotherapy 20091026 1


Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells within the biofilm may be exposed to a sublethal concentration of the antimicrobial due to the metabolic and phenotypic diversity of the biofilm-associated cells or the protection offered by the biof  ...[more]

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