Vitamin D modulation of innate immune signalling in Dendritic Cells
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ABSTRACT: Vitamin D is widely reported to inhibit innate immune signalling and dendritic cell (DC) maturation, leading to attenuation of DC mediated T cell activation as a potential immunoregulatory mechanism to guard against autoimmunity and immmunopathology. It is not known whether vitamin D has global or gene specific effects on transcriptional responses downstream of innate immune stimulation. In order to address this question, we used genome-wide transcriptional profiling of monocyte derived DC differentiated in the presence and absence of vitamin D, and then stimulated with and without lipopolysaccharide for four hours.
ORGANISM(S): Homo sapiens
SUBMITTER: Mahdad Noursadeghi
PROVIDER: E-MTAB-4883 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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