Vitamin D modulation of innate immune signalling in Dendritic Cells

ABSTRACT: Vitamin D is widely reported to inhibit innate immune signalling and dendritic cell (DC) maturation, leading to attenuation of DC mediated T cell activation as a potential immunoregulatory mechanism to guard against autoimmunity and immmunopathology. It is not known whether vitamin D has global or gene specific effects on transcriptional responses downstream of innate immune stimulation. In order to address this question, we used genome-wide transcriptional profiling of monocyte derived DC differentiated in the presence and absence of vitamin D, and then stimulated with and without lipopolysaccharide for four hours.

ORGANISM(S): Homo sapiens

SUBMITTER: Mahdad Noursadeghi 

PROVIDER: E-MTAB-4883 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress