Epithelial-mesenchymal transition-associated mRNA signature between EMT(+) and EMT(-) samples in clear-cell renal cell carcinoma
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ABSTRACT: By use of large-scale mRNA expression profiling we identified mRNAs with significantly different expression in epithelial-mesenchymal transition (EMT)-positive tumors and selected mRNAs for training phase of the study to evaluate their diagnostic and prognostic potential. Further, mRNAs were forwarded to validation phase, where all evaluated mRNA candidates were confirmed to be significantly deregulated in tumor tissue, some of them significantly differed in metastatic tumors, correlated with clinical stage, with Fuhrman grade and with overall survival.
INSTRUMENT(S): Affymetrix GeneChip Scanner 3000
ORGANISM(S): Homo sapiens
SUBMITTER: Ondrej Slaby
PROVIDER: E-MTAB-4909 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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