Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500, Covaris S2
ORGANISM(S): Homo sapiens
SUBMITTER: Claudia Pommerenke
PROVIDER: E-MTAB-4956 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Quentmeier Hilmar H Pommerenke Claudia C Ammerpohl Ole O Geffers Robert R Hauer Vivien V MacLeod Roderick A F RA Nagel Stefan S Romani Julia J Rosati Emanuela E Rosén Anders A Uphoff Cord C CC Zaborski Margarete M Drexler Hans G HG
Oncotarget 20160901 39
Genetic heterogeneity though common in tumors has been rarely documented in cell lines. To examine how often B-lymphoma cell lines are comprised of subclones, we performed immunoglobulin (IG) heavy chain hypermutation analysis. Revealing that subclones are not rare in B-cell lymphoma cell lines, 6/49 IG hypermutated cell lines (12%) consisted of subclones with individual IG mutations. Subclones were also identified in 2/284 leukemia/lymphoma cell lines exhibiting bimodal CD marker expression. We ...[more]