Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Lymphoblast
DISEASE(S): Burkitt Lymphoma
SUBMITTER: Niclas Olsson
LAB HEAD: Joshua E Elias
PROVIDER: PXD005704 | Pride | 2017-03-27
REPOSITORIES: Pride
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Nature 20170322 7647
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interrogates tumour antigen peptides presented by major histocompatibility complex (MHC) class I and class II molecules. We applied this approach to systematically characterize MHC ligand ...[more]