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Unknown,Transcriptomics,Genomics,Proteomics

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Whole genome gene expression analysis of a genomic mouse model of tauopathy

ABSTRACT: The goal of this study was to assess the number and types of differentially expressed genes in a transgenic (genomic) mouse model of tau pathology. Notably, we crossed previously described genomic mouse line called â8câ that expresses all isoforms of human tau protein (Duff et al., Neurobiology of Disease, 2000;7(2):87) with a mouse tau knockout line (Dawson et al., J Cell Sci 2001;114:1179) and generated humanized mice line called âhTau Dk/Dkâ. These mice are complete knockout of endogenous mouse tau and express all six isoforms of human tau driven by the endogenous human tau promoter. We performed microarray analysis in the hippocampal tissue from six-month old hTau Dk/Dk mice (n=3) and compared it with age-matched non-transgenic control group. Both the lines are in C57BL/6J genetic background.

INSTRUMENT(S): MouseWG-6_V2_0_R3_11278593_A

ORGANISM(S): Mus musculus

SUBMITTER: Kiran Bhaskar

PROVIDER: E-MTAB-5078 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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