Mutant Cd36 and Wars2 genes affect mass and function of brown adipose tissue in spontaneously hypertensive rats
Ontology highlight
ABSTRACT: Brown adipose tissue (BAT) was suggested to play an important role in lipid and glucose metabolism in rodents and possibly also in humans. In the current study, we used genetic and correlation analyses in the BXH/HXB recombinant inbred (RI) strains, derived from Brown Norway (BN) and spontaneously hypertensive rats (SHR), to identify genetic determinants of BAT function and its role in the pathogenesis of metabolic disturbances. Linkage analyses revealed significant quantitative trait locus (QTL) associated with interscapular BAT mass in the vicinity of the Cd36 (fatty acid translocase) gene on chromosome 4. Additional two closely linked QTL asociated with glucose oxidation and incorporation into BAT lipids were detected near the Wars2 (tryptophanyl tRNA synthetase 2, mitochondrial) candidate gene on chromosome 2.
ORGANISM(S): Rattus norvegicus
SUBMITTER: Petr Mlejnek
PROVIDER: E-MTAB-5292 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
ACCESS DATA