Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Mutant Cd36 and Wars2 genes affect mass and function of brown adipose tissue in spontaneously hypertensive rats


ABSTRACT: Brown adipose tissue (BAT) was suggested to play an important role in lipid and glucose metabolism in rodents and possibly also in humans. In the current study, we used genetic and correlation analyses in the BXH/HXB recombinant inbred (RI) strains, derived from Brown Norway (BN) and spontaneously hypertensive rats (SHR), to identify genetic determinants of BAT function and its role in the pathogenesis of metabolic disturbances. Linkage analyses revealed significant quantitative trait locus (QTL) associated with interscapular BAT mass in the vicinity of the Cd36 (fatty acid translocase) gene on chromosome 4. Additional two closely linked QTL asociated with glucose oxidation and incorporation into BAT lipids were detected near the Wars2 (tryptophanyl tRNA synthetase 2, mitochondrial) candidate gene on chromosome 2.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Petr Mlejnek 

PROVIDER: E-MTAB-5292 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2013-07-19 | E-MTAB-1702 | biostudies-arrayexpress
2017-01-15 | E-MTAB-5079 | biostudies-arrayexpress
2016-07-03 | E-MTAB-3787 | biostudies-arrayexpress
2016-07-03 | E-MTAB-3791 | biostudies-arrayexpress
2022-02-28 | E-MTAB-11414 | biostudies-arrayexpress
2015-12-31 | E-MTAB-2406 | biostudies-arrayexpress
2016-07-03 | E-MTAB-3831 | biostudies-arrayexpress
2007-09-13 | E-GEOD-1775 | biostudies-arrayexpress
2012-06-20 | E-MEXP-3492 | biostudies-arrayexpress
2013-03-18 | E-GEOD-43763 | biostudies-arrayexpress