Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of mouse pancreatic pericytes from wild-type and Tcf7l2-mutated mice

ABSTRACT: To characterise their gene expression, wild type pancreatic pericytes were isolated based on the YFP-labeling from Nkx3.2-Cre;EYFP mice. As control, whole isolated islets were analysed.To identify Tcf7l2-depenedent genes, pancreatic pericytes were isolated from Nkx3.2-Cre;EYFP;Tcf7l2 flox/flox transgenic mice, and compared to wild type cells.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Limor Landsman 

PROVIDER: E-MTAB-5325 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Polymorphism in <i>TCF7L2</i>, a component of the canonical Wnt signaling pathway, has a strong association with β-cell dysfunction and type 2 diabetes through a mechanism that has yet to be defined. β-Cells rely on cells in their microenvironment, including pericytes, for their proper function. Here, we show that Tcf7l2 activity in pancreatic pericytes is required for β-cell function. Transgenic mice in which Tcf7l2 was selectively inactivated in their pancreatic pericytes exhibited impaired gl  ...[more]