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Microarray analysis of the Lysosome-dependent activation of human dendritic cells by the vaccine adjuvant QS-21.

ABSTRACT: QS-21 is a component of the Adjuvant System AS01 that is used in several vaccine candidates. QS-21 strongly potentiates both cellular and humoral immune responses to purified antigens, yet how it activates immune cells is largely unknown. Here, QS-21 (or DQ) directly activated human monocyte-derived dendritic cells (moDCs) and promoted a pro-inflammatory transcriptional program.

ORGANISM(S): Homo sapiens

SUBMITTER: Viviane Bechtold

PROVIDER: E-MTAB-5388 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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