Unknown,Transcriptomics,Genomics,Proteomics

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Osteoarthritic Bone Marrow Lesions exhibit cystic, vascular, osteogenic and chondrogenic changes with upregulated neuronal, inflammatory and matrix gene expression signatures


ABSTRACT: Bone marrow lesions (BML) are well described in osteoarthritis (OA) using magnetic resonance imaging (MRI) and associate with pain however, little is known about their role in disease process and pattern of gene expression within the lesions. This study evaluated the gene expression profile of OA BML (n=14) in comparison to normal bone (n=10) by microarray profiling. MR imaging and the MOAKS scoring was used to locate lesions and the scaled axial images were used to sample BMLs. The bone tissue controls were harvested from participants undergoing surgery following trauma.

INSTRUMENT(S): Agilent SureScan High-Resolution DNA Microarray Scanner

ORGANISM(S): Homo sapiens

SUBMITTER: Ken Laing 

PROVIDER: E-MTAB-5564 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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