Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Juan Oliveros
PROVIDER: E-GEOD-63745 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ogando Jesús J Tardáguila Manuel M Díaz-Alderete Andrea A Usategui Alicia A Miranda-Ramos Vanessa V Martínez-Herrera Dannys Jorge DJ de la Fuente Lorena L García-León María J MJ Moreno María C MC Escudero Sara S Cañete Juan D JD Toribio María L ML Cases Ildefonso I Pascual-Montano Alberto A Pablos José Luis JL Mañes Santos S
Scientific reports 20160203
Evidence links aryl hydrocarbon receptor (AHR) activation to rheumatoid arthritis (RA) pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory cytokine expression in macrophages, pivotal cells in RA aetiopathogenesis, which hints at specific circuits that regulate the AHR pathway in RA macrophages. We compared microRNA (miR) expression in CD14(+) cells from patients with active RA or with osteoarthritis (OA). Seven miR were downregulated and one (miR-223) upregulat ...[more]