Cytokine-mediated natural killer cells effects impair hematopoietic stem cell function
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ABSTRACT: We demonstrated that NK cell activity affects HSCs frequency in vitro as well as hematopoietic reconstitution in vivo. Gene expression and cytokine profile assays revealed the potential players of this HSC-NK cell regulation, such as IFNγ. Besides the known role of C/EBPg in NK cell differentiation, we demonstrated that it is also essential for NK-cytokine mediated HSC regulation. Finally, NK cell depletion from murine and human bone marrow favored transplant chimerism.
ORGANISM(S): Mus musculus
SUBMITTER: Meritxel Alberich-Jorda
PROVIDER: E-MTAB-5604 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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