Gene expression profiles for genetically engineered murine hepatoma Hepa8F5 cells treated with or without doxycycline, cultured as monolayer or spheroids
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ABSTRACT: We developed genetically engineered Hepa/8F5 cells (available from RIKEN BioResource Center [RCB4661]), in which genes of eight liver-enriched transcription factors (LETFs)—hepatocyte nuclear factor (HNF)-1α, HNF-1β, HNF-3β [FOXA2], HNF-4α, HNF-6, CCAAT/enhancer binding protein (C/EBP)-α, C/EBP-β and C/EBP-γ—were transduced into murine hepatoma Hepa1-6 cells as drug-inducible expression cassettes [Biochem. Eng. J., 60, 67–73 (2012)]. Hepa/8F5 cells can induce high liver functions by the addition of an inducer drug (doxycycline; Dox) via overexpression of LETF genes.
ORGANISM(S): Mus musculus
SUBMITTER: Masamichi Kamihira
PROVIDER: E-MTAB-5770 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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