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Expression profile analysis of inflammatory response regulated by hepatocyte nuclear factor 4α

ABSTRACT: To obtain a genomic view of hepatocyte nuclear factor-4α (HNF-4α) in the regulation of the inflammatory response, microarray analysis was used to probe the expression profile of an inflammatory response induced by cytokines in a model of knock-down HNF-4α HepG2 cells. The results indicate an extensive role for HNF-4α plays in the regulation of a large number of the liver-specific genes. Majority of genes (71%) affected by cytokine treatment are also affected by HNF-4α knock-down. This significant overlap suggests that HNF-4α may play a role in regulating the cytokine-induced inflammatory response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE15991 | GEO | 2009/05/06

SECONDARY ACCESSION(S): PRJNA115349

REPOSITORIES: GEO

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