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Unknown,Transcriptomics,Genomics,Proteomics

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Possible role of Adrenomedullin and PLAUR in Hereditary Angioedema attacks: a transcriptomic analysis

ABSTRACT: Hereditary Angioedema (HAE) due to C1-inhibitor deficiency is a lifelong illness characterized by recurrent acute attacks of localized edema. Next to the identified role of dys-regulation in the kallikrein/bradykinin pathway at endothelial cell level, the involvement of circulating leucocytes (PBMC) in acute attacks is not yet clarified. To gain further insight into this process, we performed a PBMC microarray gene expression analysis on RNA isolated from patients with HAE comparing the transcriptome profile of acute attack with the remission phase.

ORGANISM(S): Homo sapiens

SUBMITTER: Fabio Sallustio

PROVIDER: E-MTAB-5897 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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