Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Effects on adult testis of Sertoli cell-specific ablation of miR-17-92 in mouse embryos

ABSTRACT: We induced specific deletion of miR-17-92 in Sertoli cells at the time of Amh expression in mouse embryos. We analyzed the effect of this deletion in the long term in adult testis. The transcriptome of mutant testis was consistently altered but do not produce a phenotype due to the testis homeostasis.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Miguel Burgos

PROVIDER: E-MTAB-5914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Sertoli cell-specific ablation of miR-17-92 cluster significantly alters whole testis transcriptome without apparent phenotypic effects.

Hurtado Alicia A Real Francisca M FM Palomino Rogelio R Carmona Francisco David FD Burgos Miguel M Jiménez Rafael R Barrionuevo Francisco J FJ

PloS one 20180524 5

MicroRNAs are frequently organized into polycistronic clusters whose transcription is controlled by a single promoter. The miR-17-92 cluster is expressed in most embryonic and postnatal organs. It is a potent oncogene associated to several types of cancer and it is involved in several important developmental processes. In the testis, expression of the miR-17-92 cluster in the germ cells is necessary to maintain normal spermatogenesis. This cluster is also expressed in Sertoli cells (the somatic ...[more]

PMID: 29795630

Publication: 1/2

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Dataset Information

Effects on adult testis of Sertoli cell-specific ablation of miR-17-92 in mouse embryos

Publications

Sertoli cell-specific ablation of miR-17-92 cluster significantly alters whole testis transcriptome without apparent phenotypic effects.

Similar Datasets

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