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Methylation arrays elucidate 5mC and 5hmC levels of human glioblastoma cell line LN229 upon restoration of TET3 expression.

ABSTRACT: DNA hydroxymethylation is frequently lost in glioblastoma. We hypothesized that reduced 5hmC levels might be related to the impaired expression of TET proteins in brain tumors. In this study we performed a genome-wide methylation analysis of LN229 cells stably transfected with scramble or TET3 overexpressing vectors. TET3 overexpression partially restored the genome-wide patterns of 5hmC characteristic of control brain samples in glioblastoma cell lines.

ORGANISM(S): Homo sapiens

SUBMITTER: Mario F. Fraga

PROVIDER: E-MTAB-6001 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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