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Genomic profiling of the FaDu cell line and derived subclones using amplicon-based targeted sequencing

ABSTRACT: Mutational profiling by targeted next-generation sequencing of a SCCHN cell line model and single-cell derived subclones displaying varying sensitivity to cisplatin was used to determine the extent of intratumoral heterogeneity and to dissect the molecular mechanisms involved in primary cisplatin resistance and treatment-induced clonal evolution.

INSTRUMENT(S): Illumina MiSeq

ORGANISM(S): Homo sapiens

SUBMITTER: Ingeborg Tinhofer

PROVIDER: E-MTAB-6021 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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