Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Whole-Genome Gene Expression Bead Array analysis of Toll-like receptor 2/8 stimulated human monocytes


ABSTRACT: Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through innate receptors such as Toll-like receptors (TLRs). We investigated a phenomenon where co-signaling from TLR2 and TLR8 in human primary monocytes provides a distinct immune activation profile compared to signaling from either TLR alone. Comparison of gene signatures induced by either stimulus alone or together, show that co-signaling result in downstream differences in regulation of signaling and gene transcription. To investigate the interaction of TLR2 and TLR8 stimulation primary human monocytes isolated from buffy coat were stimulated with TLR2/6 ligand FSL-1 and/or TLR7/8 ligand CL075 and the gene expression monitored at 1,2 and 3h post stimulation.

ORGANISM(S): Homo sapiens

SUBMITTER: Bjarte Bergstrøm 

PROVIDER: E-MTAB-6222 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2022-05-13 | GSE181889 | GEO
2022-05-13 | GSE181886 | GEO
2014-12-24 | E-GEOD-64480 | biostudies-arrayexpress
2012-03-15 | E-GEOD-34156 | biostudies-arrayexpress
2013-06-01 | E-GEOD-44785 | biostudies-arrayexpress
2016-04-06 | E-GEOD-68255 | biostudies-arrayexpress
2011-01-11 | E-GEOD-26470 | biostudies-arrayexpress
2023-05-10 | PXD036036 | Pride
2011-11-04 | GSE33449 | GEO
2011-11-04 | E-GEOD-33449 | biostudies-arrayexpress