LXR and RAR activation modulate TREM-1 expression in dendritic cells
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ABSTRACT: Dendritic cells (DCs) play a crucial role in the regulation of innate and adaptive immune responses. DCs initiate adaptive immune responses after their migration to secondary lymphoid organs, a process mainly driven by the expression of the chemokine receptor CCR7. LXR ligands/oxysterols released by tumors were shown to dampen DC migration to secondary lymphoid organs by the inhibition of CCR7 expression. We studied the gene expression modulation of DCs undergoing maturation (by LPS) in the presence of the oxysterol 22R-Hydroxycholesterol (22R-HC).
ORGANISM(S): Homo sapiens
SUBMITTER: Cristina Battaglia
PROVIDER: E-MTAB-6224 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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