Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: William Chang
PROVIDER: E-GEOD-7095 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chang W L William WL Baumgarth Nicole N Eberhardt Meghan K MK Lee C Y Daniel CY Baron Colin A CA Gregg Jeff P JP Barry Peter A PA
Journal of immunology (Baltimore, Md. : 1950) 20070601 12
Dendritic cells (DC) are essential for the initiation of primary adaptive immune responses, and their functionality is strongly down-modulated by IL-10. Both innate and adaptive immune signals trigger the up-regulation of antiapoptotic Bcl-2 family members to facilitate the survival of DCs after maturation. However, whether IL-10 alters the expression of apoptotic-related genes in maturing DCs has not been determined. In this study, we demonstrate that spontaneous apoptosis rapidly occurred in m ...[more]