Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression comparison of MCF10A cells with and without extra centrosomes through overexpression of PLK4


ABSTRACT: The presence of extra centrosomes is a feature of human tumours. However, it is unclear what are the changes elicited by the presence of these abnormalities. To determine the changes in gene expression induced by centrosome amplification, human mammary epithelial cells, MCF10A, expressing a doxycycline inducible PLK4 cDNA were used. Centrosome amplification was induced for 48 hrs upon the addition of doxycyclin to the culture medium. RNA was purified from MCF10A cells without extra centrosomes (no dox) and with extra centrosomes (dox) and processed for microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Susana Godinho 

PROVIDER: E-MTAB-6415 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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