Gene expression in mitotic tissues of Drosophila larvae without centrosomes or too many centrosomes
Ontology highlight
ABSTRACT: Centrosome defects are a common feature of many cancers. Surprisingly, flies can proceed through the majority of development without centrosomes or with amplified centrosomes in most of their cells. It is unclear whether this is because centrosome defects do not cause many problems in Drosophila cells, or because they can adapt to cope with any problems that arise. Indeed, centrosome loss and centrosome amplification predispose fly brain cells to form tumours. Here we assess how centrosome loss or centrosome amplification perturbs cell physiology by profiling the global transcriptome of Drosophila larval brains and imaginal discs that either lack centrosomes or have too many centrosomes.
ORGANISM(S): Drosophila melanogaster
PROVIDER: GSE35240 | GEO | 2012/08/20
SECONDARY ACCESSION(S): PRJNA152759
REPOSITORIES: GEO
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