Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of human skin lesions diagnosed as actinic keratosis, intraepidermal carcinoma or squamous cell carcinoma


ABSTRACT: We report whole tissue RNA-seq data captured from 25 AK, IEC or SCC lesions obtained from the skin of 17 individuals. We used RNA-seq to detect and measure HPV E7 transcription.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Samuel Lukowski 

PROVIDER: E-MTAB-6430 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis.

Lukowski Samuel W SW   Tuong Zewen K ZK   Noske Katharina K   Senabouth Anne A   Nguyen Quan H QH   Andersen Stacey B SB   Soyer H Peter HP   Frazer Ian H IH   Powell Joseph E JE  

The Journal of investigative dermatology 20180630 12


Persistent human papillomavirus (HPV) infection is responsible for at least 5% of human malignancies. Most HPV-associated cancers are initiated by the HPV16 genotype, as confirmed by detection of integrated HPV DNA in cells of oral and anogenital epithelial cancers. However, single-cell RNA sequencing may enable prediction of HPV involvement in carcinogenesis at other sites. We conducted single-cell RNA sequencing on keratinocytes from a mouse transgenic for the E7 gene of HPV16 and showed sensi  ...[more]

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