Transcriptional profiling of neonatal cord blood from babies born with or without prolonged rupture of membranes.
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ABSTRACT: Prolonged rupture of membranes (PROM) is thought to incur higher risk of neonatal infection, leading to expedited delivery and/or the use of empirical perinatal antibiotics. Here, we compared the transcriptional profile of neonatal cord blood between babies where rupture of membranes occurred greater than 24 hours before delivery (= PROM cases) and babies where rupture of membranes occurred less than 24 hours before delivery (= Control cases). On the basis that perinatal infection is more likely in births associated with PROM than those without, we tested the hypothesis that perinatal infection in a subset of births following PROM, exhibit immune responses evident in the neonatal cord blood transcriptome.
ORGANISM(S): Homo sapiens
SUBMITTER: Carolin Turner
PROVIDER: E-MTAB-6431 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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