RNA-seq of differential gene expression in response to teixobactin in Enterococcus faecalis

ABSTRACT: Teixobactin is the first novel antimicrobial to be discovered in decades and represents a new class of antimicrobials. Teixobactin shows great promise with proven efficacy against multi-drug resistant organisms such as methicillin-resistant S. aureus (MRSA), vancomycin-resistant Enterococci (VRE), and Mycobacterium tuberculosis. VRE infections are notoriously difficult to treat with complex and adaptable cell wall stress response systems, which confer intrinsic resistance to a wide variety of antimicrobials. The aim of this study was to isolate the teixobactin-induced transcriptional response by challenging lab strain Enterococcus faecalis JH2-2 with sub-MIC levels of teixobactin using RNA sequencing. Two cultures of E. faecalis were grown to an OD600 of 0.2 and subsequently split into th

INSTRUMENT(S): Illumina MiSeq

ORGANISM(S): Enterococcus faecalis

SUBMITTER: Rachel Darnell 

PROVIDER: E-MTAB-6484 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress