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Antigen specific TGF-beta-induced regulatory T cells secrete chemokines, regulate T cell trafficking, and suppress ongoing autoimmunity

ABSTRACT: activated and resting TGF-beta induced regulatory T cells

ORGANISM(S): Mus musculus

SUBMITTER: Richard DiPaolo

PROVIDER: E-MTAB-660 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Antigen-specific TGF-β-induced regulatory T cells secrete chemokines, regulate T cell trafficking, and suppress ongoing autoimmunity.

Nguyen Thanh-Long M TL Sullivan Nicole L NL Ebel Mark M Teague Ryan M RM DiPaolo Richard J RJ

Journal of immunology (Baltimore, Md. : 1950) 20110711 4

The ability to regulate ongoing inflammation using regulatory T cells (Tregs) is under intense investigation. Strategies to induce and expand Ag-specific Tregs are being developed, and whether various types of Tregs are suppressive in the inflammatory conditions associated with ongoing disease needs to be determined. In this study, we report that TGF-β-induced Tregs (iTregs) and expanded Tregs specific for a major self-Ag in autoimmune gastritis suppress inflammation and associated pathology whe ...[more]

PMID: 21746962

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