Transcriptional Profiling of Synovium in a Porcine Model of Early Post-traumatic Osteoarthritis
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ABSTRACT: 36 Yucatan minipigs underwent anterior cruciate ligament (ACL) transection and were randomly assigned in equal numbers to no further treatment, reconstruction or ligament repair. Peri-meniscal synovium was harvested at 1 and 4 weeks post-operatively and histology and RNA-sequencing performed. The generated data served to identify the molecular pathophysiology present in inflamed synovium during the early development of post-traumatic osteoarthritis (PTOA), as well as differences between surgical treatments.
INSTRUMENT(S): Illumina HiSeq 2500
ORGANISM(S): Sus scrofa
SUBMITTER: Jakob Sieker
PROVIDER: E-MTAB-6664 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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