Proteomics

Dataset Information

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Comprehensive proteomic comparison between native tendon and ligament and 3D tissue engineered tendon and ligament constructs


ABSTRACT: Tendons and ligaments are important biological structures in both humans and animals. They are part of dense connective tissue and are crucial to the functioning of the musculoskeletal system. However, they are commonly damaged due to age-related wear and tear, trauma or sports related incidents, which can lead to severe immobility for the individual and can lead to injury of other tissues and development of degenerative joint disease such as osteoarthritis. Tissue engineering can offer great potential in the treatment of tendon and ligament injury by seeking a biological replacement with fully regenerated autologenous tissue. This approach commonly involves an artificial ECM (scaffold) on which cell can proliferate and differentiate with subsequent new tissue generation. Fibrin is a natural scaffold with no expected toxic degradation or inflammatory reaction and can be used as an autologous scaffold for fibroblast from connective tissue to create a three dimensional structure. The purpose of this study was to compare the proteomic differences between native tendon, ligament and 3D tissue engineered tendon and ligament fibrin constructs.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Canis Familiaris (dog) (canis Lupus Familiaris)

TISSUE(S): Connective Tissue, Fibroblast, Tendon

SUBMITTER: Yalda Ashraf Kharaz  

LAB HEAD: EIthne Comerford

PROVIDER: PXD003094 | Pride | 2016-06-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
3D_ACL_A.mgf Mgf
3D_ACL_A.pride.mgf.gz Mgf
3D_ACL_A.raw Raw
3D_ACL_B.mgf Mgf
3D_ACL_B.pride.mgf.gz Mgf
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Publications

Proteomic differences between native and tissue-engineered tendon and ligament.

Kharaz Yalda A YA   Tew Simon R SR   Peffers Mandy M   Canty-Laird Elizabeth G EG   Comerford Eithne E  

Proteomics 20160501 10


Tendons and ligaments (T/Ls) play key roles in the musculoskeletal system, but they are susceptible to traumatic or age-related rupture, leading to severe morbidity as well as increased susceptibility to degenerative joint diseases such as osteoarthritis. Tissue engineering represents an attractive therapeutic approach to treating T/L injury but it is hampered by our poor understanding of the defining characteristics of the two tissues. The present study aimed to determine differences in the pro  ...[more]

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