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Gene expression profile of microdissected mucinous ovarian tumors


ABSTRACT: Gene expression profile of 8 mucinous borderline ovarian tumors and 9 mucinous ovarian carcinomas. Frozen tumor samples were laser-capture microdissected for their epithelial component. RNA was extracted. Gene expression profiling was completed using Affymetrix U133 Plus 2.0 oligonucleotide microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Intidhar Labidi-Galy 

PROVIDER: E-MTAB-6844 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Expression profiling of mucinous tumors of the ovary identifies genes of clinicopathologic importance.

Wamunyokoli Fred W FW   Bonome Tomas T   Lee Ji-Young JY   Feltmate Colleen M CM   Welch William R WR   Radonovich Mike M   Pise-Masison Cindy C   Brady John J   Hao Ke K   Berkowitz Ross S RS   Mok Samuel S   Birrer Michael J MJ  

Clinical cancer research : an official journal of the American Association for Cancer Research 20060201 3 Pt 1


<h4>Purpose</h4>To elucidate the molecular mechanisms contributing to the unique clinicopathologic characteristics of mucinous ovarian carcinoma, global gene expression profiling of mucinous ovarian tumors was carried out.<h4>Experimental design</h4>Gene expression profiling was completed for 25 microdissected mucinous tumors [6 cystadenomas, 10 low malignant potential (LMP) tumors, and 9 adenocarcinomas] using Affymetrix U133 Plus 2.0 oligonucleotide microarrays. Hierarchical clustering and bin  ...[more]

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