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MiRNA profiling of mixoid liposarcoma cell lines sensitive and resistant to trabectidin

ABSTRACT: This investigation aims at identifying differentially expressed miRNA between two cell lines, MLS 402-91 (sensitive to trabectidin) and MLS 402-91/ET (resistant to trabectidin).

ORGANISM(S): Homo sapiens

SUBMITTER: Luca Beltrame

PROVIDER: E-MTAB-695 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma.

Uboldi Sarah S Calura Enrica E Beltrame Luca L Fuso Nerini Ilaria I Marchini Sergio S Cavalieri Duccio D Erba Eugenio E Chiorino Giovanna G Ostano Paola P D'Angelo Daniela D D'Incalci Maurizio M Romualdi Chiara C

PloS one 20120416 4

Trabectedin, a new antitumor compound originally derived from a marine tunicate, is clinically effective in soft tissue sarcoma. The drug has shown a high selectivity for myxoid liposarcoma, characterized by the translocation t(12;16)(q13; p11) leading to the expression of FUS-CHOP fusion gene. Trabectedin appears to act interfering with mechanisms of transcription regulation. In particular, the transactivating activity of FUS-CHOP was found to be impaired by trabectedin treatment. Even after pr ...[more]

PMID: 22523595

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