Transcription profiling time series of lymphocytes from patients with B chronic lymphocytic leukemia treated with fludarabine to identify a signature of drug resistance
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Arnaud Muller
PROVIDER: E-MTAB-70 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia.
Moussay Etienne E Palissot Valérie V Vallar Laurent L Poirel Hélène A HA Wenner Thomas T El Khoury Victoria V Aouali Nasséra N Van Moer Kris K Leners Bernadette B Bernardin François F Muller Arnaud A Cornillet-Lefebvre Pascale P Delmer Alain A Duhem Caroline C Ries Fernand F van Dyck Eric E Berchem Guy G
Molecular cancer 20100520
<h4>Background</h4>Chronic lymphocytic leukemia (CLL) cells are often affected by genomic aberrations targeting key regulatory genes. Although fludarabine is the standard first line therapy to treat CLL, only few data are available about the resistance of B cells to this purine nucleoside analog in vivo. Here we sought to increase our understanding of fludarabine action and describe the mechanisms leading to resistance in vivo. We performed an analysis of genomic aberrations, gene expression pro ...[more]
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