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STRT RNAseq of THP-1 monocytic cells exposed to surface modified-gold nanoparticles

ABSTRACT: Transcriptome comparison to assess the responses of human monocytic cells (THP-1) to gold-nanoparticles (Au-NPs) of two different diameter sizes (5 or 20 nm) with different surface functional groups, i.e., alkylammonium bromide, alkyl sodium carboxylate, or poly(ethylene glycol) (PEG)-terminated thiolate Au-NPs.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Audrey Gallud

PROVIDER: E-MTAB-7093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study.

Gallud Audrey A Klöditz Katharina K Ytterberg Jimmy J Östberg Nataliya N Katayama Shintaro S Skoog Tiina T Gogvadze Vladimir V Chen Yu-Zen YZ Xue Ding D Moya Sergio S Ruiz Jaime J Astruc Didier D Zubarev Roman R Kere Juha J Fadeel Bengt B

Scientific reports 20190313 1

Systems biology is increasingly being applied in nanosafety research for observing and predicting the biological perturbations inflicted by exposure to nanoparticles (NPs). In the present study, we used a combined transcriptomics and proteomics approach to assess the responses of human monocytic cells to Au-NPs of two different sizes with three different surface functional groups, i.e., alkyl ammonium bromide, alkyl sodium carboxylate, or poly(ethylene glycol) (PEG)-terminated Au-NPs. Cytotoxici ...[more]

PMID: 30867451

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