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Overexpression of spliced XBP1 in in vitro Th2 cells, and comparison to 4u8c treatment

ABSTRACT: This experiment shows that the in vitro effect of 4u8c on Th2 cells can be rescued using XBP1s overexpression

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Johan Henriksson

PROVIDER: E-MTAB-7104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.

Pramanik Jhuma J Chen Xi X Kar Gozde G Henriksson Johan J Gomes Tomás T Park Jong-Eun JE Natarajan Kedar K Meyer Kerstin B KB Miao Zhichao Z McKenzie Andrew N J ANJ Mahata Bidesh B Teichmann Sarah A SA

Genome medicine 20181024 1

<h4>Background</h4>The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity. In the immune system, it is known to function in dendritic cells, plasma cells, and eosinophil development and differentiation, while its role in T helper cell is unexplored. Here, we investigated the role of the IRE1a-XBP1 pathway in regulating activation ...[more]

PMID: 30355343

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