Analysis of Escherichia coli adaptation to sublethal concentrations of sodium bisulfite
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ABSTRACT: Little is known about cell survival in the presence of reducing reagents, likewise changing the redox state of living organisms and, therefore potentially conferring a negative effect on respiration and major metabolic pathways. We employed Escherichia coli as a model organism to analyze its responses to sublethal concentrations of sodium sulfite, one of the common food preservatives used for inhibition of microbial growth. We found that partial inhibition of E. coli growth by sodium sulfite was accompanied by profound changes in gene expression. Besides affecting major metabolic pathways, these changes apparently led to reduced production of flagellar proteins, thus potentially impacting cell motility. Concomitantly, E. coli upregulated a number of genes involved in repair of macromolecules and antisense control.
ORGANISM(S): Escherichia coli
SUBMITTER: Ion Luis Abad Recio
PROVIDER: E-MTAB-7120 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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