Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

MRNA expression changes in chicken livers associated with field exposure to DDTs in KwaZulu-Natal, South Africa

ABSTRACT: Free-range chickens were sampled from homesteads in South Africa where DDT is sprayed for malaria control. The purpose was to detect potential effects associated with contamination. Livers were sampled post-mortem & analysed for DDTs (DDT and metabolites) contamination. Samples from two birds were further processed by microarray analysis – one with a relatively low (1,116.0 ng/g wet weight; sample SA1) and one with a relatively high (1,938.0 ng/g wet weight; sample SA2) level of contamination by DDTs.

INSTRUMENT(S): Agilent Technologies Microarray Scanner

ORGANISM(S): Gallus gallus

SUBMITTER: Lesa Thompson

PROVIDER: E-MTAB-7130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Investigation of mRNA expression changes associated with field exposure to DDTs in chickens from KwaZulu-Natal, South Africa.

Thompson Lesa A LA Ikenaka Yoshinori Y Darwish Wageh S WS Yohannes Yared B YB van Vuren Johan J JJ Wepener Victor V Smit Nico J NJ Assefa Atnafu G AG Tharwat Ahmed A Eldin Walaa Fathy Saad WFS Nakayama Shouta M M SMM Mizukawa Hazuki H Ishizuka Mayumi M

PloS one 20181011 10

The objective of this study was to identify potential mRNA expression changes in chicken livers associated with environmental exposure to dichloro-diphenyl-trichloroethane (DDT) and its metabolites (DDTs). In particular, we focused on genes relating to the immune system and metabolism. We analyzed liver samples from free-ranging chickens in KwaZulu-Natal, South Africa, for contamination by DDTs. This area predominantly uses DDT in its malaria control program, and homes are sprayed annually with ...[more]

PMID: 30307967

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Dataset Information

MRNA expression changes in chicken livers associated with field exposure to DDTs in KwaZulu-Natal, South Africa

Publications

Investigation of mRNA expression changes associated with field exposure to DDTs in chickens from KwaZulu-Natal, South Africa.

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