Dataset Information
MRNA-seq of HCT116 RNF40 knockdown cells upon TNF-alpha stimulation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Homo sapiens
SUBMITTER: Steven Johnsen
PROVIDER: E-MTAB-7197 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.
Journal of Crohn's & colitis 20190301 3
<h4>Background and aims</h4>Inflammatory bowel diseases are linked to an increased risk of developing colorectal cancer [CRC]. Previous studies suggested that the H2B ubiquitin ligase RING finger protein-20 [RNF20] inhibited inflammatory signaling mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB]. However, the role of RNF40, the obligate heterodimeric partner of RNF20, in the context of inflammation and CRC has not been addressed. Here, we examined the effect ...[more]
