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MRNA expression of Atopic Dermatitis keratinocytes

ABSTRACT: mRNA array analysis of total RNA from primary kertinocytes from three healthy controls, three atopic dermatitis patients and three psoriasis patients was carried out

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Ana Rebane

PROVIDER: E-MTAB-728 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis.

Rebane Ana A Zimmermann Maya M Aab Alar A Baurecht Hansjörg H Koreck Andrea A Karelson Maire M Abram Kristi K Metsalu Tauno T Pihlap Maire M Meyer Norbert N Fölster-Holst Regina R Nagy Nikoletta N Kemeny Lajos L Kingo Külli K Vilo Jaak J Illig Thomas T Akdis Mübeccel M Franke Andre A Novak Natalija N Weidinger Stephan S Akdis Cezmi A CA

The Journal of allergy and clinical immunology 20120324 5

<h4>Background</h4>Enhanced apoptosis of keratinocytes is the main cause of eczema and spongiosis in patients with the common inflammatory skin disease atopic dermatitis (AD).<h4>Objective</h4>The aim of the study was to investigate molecular mechanisms of AD-related apoptosis of keratinocytes.<h4>Methods</h4>Primary keratinocytes isolated from patients with AD and healthy donors were used to study apoptosis by using annexin V/7-aminoactinomycin D staining. Illumina mRNA Expression BeadChips, qu ...[more]

PMID: 22445417

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