Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
DISEASE(S): normal
SUBMITTER: Gideon Stein
PROVIDER: E-MTAB-762 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Stein Gideon Y GY Yosef Nir N Reichman Hadar H Horev Judith J Laser-Azogui Adi A Berens Angelique A Resau James J Ruppin Eytan E Sharan Roded R Tsarfaty Ilan I
PloS one 20120925 9
To determine the signaling pathways leading from Met activation to metastasis and poor prognosis, we measured the kinetic gene alterations in breast cancer cell lines in response to HGF/SF. Using a network inference tool we analyzed the putative protein-protein interaction pathways leading from Met to these genes and studied their specificity to Met and prognostic potential. We identified a Met kinetic signature consisting of 131 genes. The signature correlates with Met activation and with respo ...[more]