Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic profiles of white adipose tissue, brown adipose tissue and liver in rats fed either a high-fat diet or high-fat diet combined with ellagic acid treatment

ABSTRACT: In this study, we assessed the effect of acute oral administration of ellagic acid on metabolic parameters, oxidative stress and transcriptomic profiles in an inbred rodent model, carrying a variant of one of the metabolic syndrome-related genes, Zbtb16 (Zinc Finger And BTB Domain Containing 16). Over a period of three weeks, adult male rats of the SHR-Lx/k.o. strain were fed a high-fat diet accompanied with daily intragastric gavage of ellagic acid (50 mg/kg body weight; HFD-EA rats) or solvent only (HFD rats). At the end of the protocol, morphometric and metabolic parameters, including glucose tolerance test, serum lipid concentration and oxidative stress markers along with transcriptomic profile of liver, brown, and epididymal adipose tissues were assessed.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ondřej Seda

PROVIDER: E-MTAB-8928 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptomic profiles of white adipose tissue, brown adipose tissue and liver in rats fed either a high-fat diet or high-fat diet combined with ellagic acid treatment

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