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MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts

ABSTRACT: Rad50 is a component of the conserved MRE11-RAD50-NBS1 (MRN) complex, which functions in genome stability and the cell’s ability to deal with stalled DNA replication forks. We identified Rad50 as a factor important for R-loop tolerance and thus mapped DNA:RNA hybrids in Rad50KO cells and compare them to previously reported wild-type and Sgs1KO profiles.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Maria Aristiabal

PROVIDER: E-MTAB-7885 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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