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Transcription profiling of of the human filarial nematode Brugia malayi across multiple life-cycle stages

ABSTRACT: High-throughput sequencing to profile the transcriptome of the human filarial nematode Brugia malayi, the causative agent of lymphatic filariasis, across multiple life-cycle stages.

ORGANISM(S): Brugia malayi

SUBMITTER: Nancy Holroyd

PROVIDER: E-MTAB-811 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi.

Choi Young-Jun YJ Ghedin Elodie E Berriman Matthew M McQuillan Jacqueline J Holroyd Nancy N Mayhew George F GF Christensen Bruce M BM Michalski Michelle L ML

PLoS neglected tropical diseases 20111213 12

<h4>Background</h4>Developing intervention strategies for the control of parasitic nematodes continues to be a significant challenge. Genomic and post-genomic approaches play an increasingly important role for providing fundamental molecular information about these parasites, thus enhancing basic as well as translational research. Here we report a comprehensive genome-wide survey of the developmental transcriptome of the human filarial parasite Brugia malayi.<h4>Methodology/principal findings</h ...[more]

PMID: 22180794

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