Microarray analysis of MDA-MB231 cell treated with the p53-reactivating molecule CP-31398
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ABSTRACT: Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors, could interfere with Granzyme B-mediated cell death, the use of small molecules developed to reactivate wtp53 function in p53-mutated tumor cells could optimize their lysis by CTL or NK cells. Here, we analyzed the transcriptomic effect of the pharmalogical reactivation of a wt-like p53 function in p53-mutated breast cancer cells using the small molecule CP-31398.
ORGANISM(S): Homo sapiens
SUBMITTER: Jerome THIERY
PROVIDER: E-MTAB-8143 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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