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Consequences of loss of spinophilin on striatal mGluR5 phosphorylation and interactome

ABSTRACT: Constitutive knockout of the obsessive-compulsive disorder-associated protein, SAPAP3, results in repetitive motor dysfunction, such as excessive grooming, caused by increased mGluR5 activity in striatal medium spiny neurons (MSNs). However, signaling mechanisms that mediate mGluR5-dependent grooming dysfunction are not fully understood. Here, we investigate the function of the striatal signaling hub protein, spinophilin, in regulating mGluR5 phosphorylation and protein interactions, which may predict spinophilin’s role in regulating mGluR5-dependent grooming dysfunction.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Emma Doud

LAB HEAD: Amber L. Mosley

PROVIDER: PXD034053 | Pride | 2022-12-14

REPOSITORIES: Pride

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			Action	DRS
	2019_11_021_R_Baucum_Morris_KO_IP.raw	Raw
	2019_11_021_R_Baucum_Morris_WT_IP.raw	Raw
	2019_11_021_R_Baucum_Morris_fixedPSM.mzML	Mzml
	2019_11_021_R_Baucum_Morris_fixedPSM.mzid.gz	Mzid
	2019_11_021_R_Baucum_Morris_fixedPSM.pdResult	Other

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