ChIP-seq for ZEB1 in the human breast cancer cell line MDA-MB-231
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500
ORGANISM(S): Homo sapiens
SUBMITTER: Simone Brabletz
PROVIDER: E-MTAB-8258 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer.
Feldker Nora N Ferrazzi Fulvia F Schuhwerk Harald H Widholz Sebastian A SA Guenther Kerstin K Frisch Isabell I Jakob Kathrin K Kleemann Julia J Riegel Dania D Bönisch Ulrike U Lukassen Sören S Eccles Rebecca L RL Schmidl Christian C Stemmler Marc P MP Brabletz Thomas T Brabletz Simone S
The EMBO journal 20200721 17
Invasion, metastasis and therapy resistance are the major cause of cancer-associated deaths, and the EMT-inducing transcription factor ZEB1 is a crucial stimulator of these processes. While work on ZEB1 has mainly focused on its role as a transcriptional repressor, it can also act as a transcriptional activator. To further understand these two modes of action, we performed a genome-wide ZEB1 binding study in triple-negative breast cancer cells. We identified ZEB1 as a novel interactor of the AP- ...[more]
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