Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dustin Schones
PROVIDER: E-GEOD-59749 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Schones Dustin E DE Chen Xiaoji X Trac Candi C Setten Ryan R Paddison Patrick J PJ
Epigenetics & chromatin 20140910
<h4>Background</h4>The formation of chromatin domains is an important step in lineage commitment. In human hematopoietic stem and progenitor cells (HSPCs), G9a/GLP-dependent H3K9me2 chromatin territories form de novo during lineage specification and are nucleated at punctate sites during lineage commitment. Here, we examined the patterning of G9a/GLP-dependent H3K9me2 in HSPCs and the consequences for chromatin structure.<h4>Results</h4>We profiled chromatin accessibility across the genome of HS ...[more]